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Am J Perinatol. 1992 Sep-Nov;9(5-6):398-400.

Prenatal presentation of congenital chloride diarrhea: clinical report and review of the literature.

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  • 1Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104.


A case of congenital chloride diarrhea was diagnosed after delivery in a patient whose antenatal course was notable for massively dilated small and large bowel and persistent, severe hydramnios refractory to therapy. The pathophysiologic mechanism is a dysfunctional chloride-bicarbonate exchange in the brush border of the ileum. Antenatal presentation, prenatal diagnosis, and a review of the current literature are discussed.

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