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Ann Emerg Med. 1992 Nov;21(11):1312-5.

Effect of sodium polystyrene sulfonate on lithium bioavailability.

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  • 1Department of Pharmacy Services, Ottawa General Hospital, Ontario, Canada.

Abstract

STUDY OBJECTIVE:

To examine the effect of a single dose of sodium polystyrene sulfonate and sorbitol on lithium absorption.

DESIGN:

Prospective, randomized, crossover.

SETTING:

University teaching hospital.

TYPE OF PARTICIPANTS:

Healthy volunteers.

INTERVENTIONS:

Subjects ingested 600 mg lithium carbonate on two occasions, with and without 30 g concomitant sodium polystyrene sulfonate. Blood samples were drawn up to 24 hours after ingestion and assayed for serum lithium concentration.

MEASUREMENTS AND MAIN RESULTS:

Compared with control, sodium polystyrene sulfonate and sorbitol reduced the area under the lithium serum concentration-time curve by 11.33%, reduced the mean observed peak serum lithium concentration 0.07 +/- 0.08 mmol/L, and delayed the time to the mean observed peak serum lithium concentration by 2.04 +/- 2.40 hours.

CONCLUSION:

Sodium polystyrene sulfonate and sorbitol may be used in patients immediately or shortly after ingestion of a significant acute overdose of lithium in situations in which hemodialysis cannot be instituted promptly.

PMID:
1416324
[PubMed - indexed for MEDLINE]
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