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    Acta Neurol Scand. 1992 Sep;86(3):275-9.

    Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.

    Verbiest HB, Straver JS, Colombo JP, van der Vijver JC, van Woerkom TC.

    Source

    Department of Neurology, Municipal Hospital Leyenburg, The Hague, The Netherlands.

    Abstract

    Valproic acid induced coma is presented in an adult patient without a history of metabolic disease. Liver biopsy revealed a reduction in activity of carbamyl phosphate synthetase-I, an enzyme obligated for transformation of ammonia to urea in the urea cycle. After recovery CT scan follow-up showed marked cerebral atrophy which did not exist prior to the state of coma. Risk factors are discussed.

    PMID:
    1414247
    [PubMed - indexed for MEDLINE]

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