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Science. 1992 Oct 16;258(5081):424-9.

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.

Author information

  • Howard Hughes Medical Institute, Section of Genetics, Duke University Medical Center, Durham, NC 27710.

Abstract

The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common mechanism of action for the oncoproteins encoded by the DNA tumor viruses.

PMID:
1411535
[PubMed - indexed for MEDLINE]
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