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    Science. 1992 Oct 16;258(5081):424-9.

    E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.

    Source

    Howard Hughes Medical Institute, Section of Genetics, Duke University Medical Center, Durham, NC 27710.

    Abstract

    The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common mechanism of action for the oncoproteins encoded by the DNA tumor viruses.

    PMID:
    1411535
    [PubMed - indexed for MEDLINE]

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