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Science. 1992 Sep 25;257(5078):1946-50.

Multiple zinc finger forms resulting from developmentally regulated alternative splicing of a transcription factor gene.

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  • 1Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.


Transcripts encoding the Drosophila putative transcription factor CF2 are subject to developmentally regulated alternative splicing, and they encode protein isoforms that differ in the number of zinc fingers. One testis-specific RNA encodes an isoform that includes three zinc fingers and a frame-shifted segment. Two other transcripts encode isoforms with six and seven zinc fingers which bind to distinct promoters and DNA target sequences. Thus, because of alternative splicing, a single gene appears to encode distinct DNA-binding proteins, each capable of regulating different gene sets in different tissues and developmental periods.

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