Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nature. 1992 Sep 24;359(6393):295-300.

Effects of an Rb mutation in the mouse.

Author information

  • 1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

Abstract

The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die between days 14 and 15 of gestation, exhibiting neuronal cell death and defective erythropoiesis.

Comment in

PMID:
1406933
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk