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Mol Microbiol. 1992 Aug;6(16):2219-24.

(A)BC excinuclease: the Escherichia coli nucleotide excision repair enzyme.

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  • 1Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill 27599.


Nucleotide excision repair is the major pathway for removing damage from DNA. (A)BC excinuclease is the nuclease activity which initiates nucleotide excision repair in Escherichia coli. In this review, we focus on current understanding of the structure-function of the enzyme and the reaction mechanism of the repair pathway. In addition, recent biochemical studies on preferential repair of actively transcribed genes in E. coli are summarized.

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