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J Rheumatol. 1992 Aug;19(8):1282-5.

SEA syndrome revisited: a longterm followup of children with a syndrome of seronegative enthesopathy and arthropathy.

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  • 1Department of Paediatrics, University of British Columbia, Vancouver, Canada.

Abstract

Thirty-six of the 39 children originally described with the syndrome of seronegative enthesopathy and arthropathy, followed for a mean of 11 years after symptom onset, were found to have had a widely varied clinical course. Twelve of the 23 patients (52%) who originally did not have a seronegative spondyloarthropathy developed definite (6) or possible (6) seronegative spondyloarthropathies. The development of a seronegative spondyloarthropathy was associated with HLA-B27 (p = 0.0004) and the presence of arthritis (rather than arthralgia only) at the time of the original report (p = 0.05). For patients with arthritis, the development of a seronegative spondyloarthropathy was associated with arthritis onset after 5 years of age (p = 0.01).

PMID:
1404167
[PubMed - indexed for MEDLINE]
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