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Gene. 1992 Oct 21;120(2):291-5.

Cloning, expression and tissue distribution of the gene encoding rat fibroblast growth factor receptor subtype 4.

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  • 1Du Pont Merck Pharmaceutical Co., Experimental Station, Wilmington, DE 19880-0400.


The rat homologue of the gene encoding the fibroblast growth factor receptor subtype 4 (FGFR4) was cloned from rat lung mRNA, and the cDNA sequence was found to be 95% similar and 92% identical to the human homologue. Northern blot analysis of adult rat tissues demonstrated that a 3.1-kb mRNA encoding FGFR4 is detectable only in the lung and kidney. The receptor variant described here encodes two potential immunoglobulin-like domains, 21 hydrophobic amino acids encoding a potential transmembrane domain, and a split tyrosine kinase motif. However, the acidic box and hydrophobic signal peptide domains are not present in this cDNA isolate.

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