Binding of HIV-1 gp120 to the nicotinic receptor. [FEBS Lett. 1992]

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1: FEBS Lett. 1992 Oct 19;311(2):115-8. Links

Binding of HIV-1 gp120 to the nicotinic receptor.

Bracci L, Lozzi L, Rustici M, Neri P.

Department of Molecular Biology, University of Siena, Italy.

We previously described a significant sequence homology between HIV-1 gp120 and the functional sites responsible for the specific binding of snake curare-mimetic neurotoxins and rabies virus glycoprotein to the nicotinic acetylcholine receptor. Here we report findings about the existence of a mechanism of functional molecular mimicry which could enable the binding of HIV-1 gp120 to nicotinic acetylcholine receptors in muscle cells and neurons.

PMID: 1397297 [PubMed - indexed for MEDLINE]

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