Periodic lateralized epileptiform discharges (PLEDs) are seen, as a rule, following acute brain damage. We presented a 54-year-old diabetic male with ischemic coronary disease. Following cardiopulmonary arrest, the patient had a particular EEG pattern of PLEDs, characterized by two recurrent discharges. To our knowledge, this is the fourth published case of such EEG alteration. All of the cases were related to anoxic events.