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Neuroreport. 1992 Jun;3(6):481-4.

The cell adhesion molecule L1 has a specific role in neural cell migration.

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  • 1Department of Physiology, Keio University School of Medicine, Tokyo, Japan.


L1-transfected L cells show a markedly enhanced ability for neuronal cell binding and promotion of neuron migration compared with control L cells. Further, when purified L1 was used as a culture substrate for neurons, it was found to promote neuronal adhesion and enhance the speed of migration of cerebellar neurons from reaggregated cultures, indicating that it is involved in a determinant step of neural cell migration.

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