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Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase.
Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637.
We have cloned and characterized the human gene for the 21-kDa brain form of prostaglandin D2 synthase. The gene was isolated from a human genomic lambda library and spans 3600 base pairs. It consists of seven exons and six introns. Southern blot analysis indicates that there is a single copy of the gene in the haploid genome. The transcriptional start site was mapped to a G residue 74 base pairs 5' of the ATG initiation codon. A TATA box-like element (ATAAATA) is situated 21 base pairs upstream of the mRNA start site. The gene was mapped to chromosome 9 bands q34.2-q34.3. The gene bears close resemblance to the genes for murine major urinary protein and ovine beta-lactoglobulin.
PMID: 1385416 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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LCN6, a novel human epididymal lipocalin.
Hamil KG, Liu Q, Sivashanmugam P, Anbalagan M, Yenugu S, Soundararajan R, Grossman G, Rao AJ, Birse CE, Ruben SM, et al.
Reprod Biol Endocrinol. 2003 Nov 14; 1:112. Epub 2003 Nov 14.
[Reprod Biol Endocrinol. 2003]
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Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients.
Eguchi Y, Eguchi N, Oda H, Seiki K, Kijima Y, Matsu-ura Y, Urade Y, Hayaishi O.
Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14689-94.
[Proc Natl Acad Sci U S A. 1997]
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Characterization of rat spleen prostaglandin H D-isomerase as a sigma-class GSH transferase.
Meyer DJ, Thomas M.
Biochem J. 1995 Nov 1; 311 ( Pt 3):739-42.
[Biochem J. 1995]