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    J Biol Chem. 1992 Nov 15;267(32):23202-8.

    Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase.

    White DM, Mikol DD, Espinosa R, Weimer B, Le Beau MM, Stefansson K.

    Source

    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637.

    Abstract

    We have cloned and characterized the human gene for the 21-kDa brain form of prostaglandin D2 synthase. The gene was isolated from a human genomic lambda library and spans 3600 base pairs. It consists of seven exons and six introns. Southern blot analysis indicates that there is a single copy of the gene in the haploid genome. The transcriptional start site was mapped to a G residue 74 base pairs 5' of the ATG initiation codon. A TATA box-like element (ATAAATA) is situated 21 base pairs upstream of the mRNA start site. The gene was mapped to chromosome 9 bands q34.2-q34.3. The gene bears close resemblance to the genes for murine major urinary protein and ovine beta-lactoglobulin.

    PMID:
    1385416
    [PubMed - indexed for MEDLINE]
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