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Characterization of the human kallikrein locus.
Department of Pathology, Erasmus University, Rotterdam, The Netherlands.
The human kallikrein gene family is composed of three members: tissue kallikrein (KLK1), prostate-specific antigen (PA or APS), and human glandular kallikrein-1 (hGK-1 or KLK2). The three genes have previously been isolated and mapped to chromosome 19q13.2-q13.4. Further analysis of an area of 110 kb surrounding the kallikrein genes by CHEF electrophoresis and chromosome walking showed clustering of the three genes. The KLK1 gene is positioned in the opposite orientation of the APS and KLK2 genes in the order KLK1-APS-KLK2. The APS and KLK2 gene are separated by 12 kb; the distance between KLK1 and APS is 31 kb. A CpG island was detected in the region between KLK1 and APS. Preliminary data indicate that this CpG island is located directly adjacent to a gene that is unrelated to the kallikreins and seems to be ubiquitously expressed.
PMID: 1385301 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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Twenty Years of PSA: From Prostate Antigen to Tumor Marker.
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[Rev Urol. 2007]
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The autolytic regulation of human kallikrein-related peptidase 6.
Blaber SI, Yoon H, Scarisbrick IA, Juliano MA, Blaber M.
Biochemistry. 2007 May 1; 46(17):5209-17. Epub 2007 Apr 7.
[Biochemistry. 2007]
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Specificity of human tissue kallikrein towards substrates containing Phe-Phe pair of amino acids.
Pimenta DC, Chao J, Chao L, Juliano MA, Juliano L.
Biochem J. 1999 Apr 15; 339 ( Pt 2):473-9.
[Biochem J. 1999]
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