Trends Pharmacol Sci. 1992 Sep;13(9):359-65.

Structural basis of voltage-gated K+ channel pharmacology.

Source

Zentrum für Molekulare Neurobiologie, Universität Hamburg, FRG.

Abstract

Major advances have been made in understanding the domains and amino acid sidechains important for the function of voltage-gated K+ channels, by combining recombinant DNA techniques with pharmacological and electrophysiological approaches. As explained in this review by Olaf Pongs, the results of these experiments have enabled description of a detailed model of the K+ channel pore structure and provide an exciting picture of how open-channel blockers occlude the pore of K+ channels. Since the pore is a highly conserved structure among voltage-gated K+ channels, there are only limited possibilities for open K+ channel blockers to distinguish between the many distinct voltage-gated K+ channels, which have diverse kinetic and conductance properties.

PMID:: 1382336; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Receptor sites for open channel blockers of Shaker voltage-gated potassium channels--molecular approaches. [J Recept Res. 1993]
Receptor sites for open channel blockers of Shaker voltage-gated potassium channels--molecular approaches.
Pongs O. J Recept Res. 1993; 13(1-4):503-12.
Predominant expression of Kv1.3 voltage-gated K+ channel subunit in rat prostate cancer cell lines: electrophysiological, pharmacological and molecular characterisation. [Pflugers Arch. 2003]
Predominant expression of Kv1.3 voltage-gated K+ channel subunit in rat prostate cancer cell lines: electrophysiological, pharmacological and molecular characterisation.
Fraser SP, Grimes JA, Diss JK, Stewart D, Dolly JO, Djamgoz MB. Pflugers Arch. 2003 Aug; 446(5):559-71. Epub 2003 Jul 1.
Alternative Shaker transcripts express either rapidly inactivating or noninactivating K+ channels. [Proc Natl Acad Sci U S A. 1990]
Alternative Shaker transcripts express either rapidly inactivating or noninactivating K+ channels.
Stocker M, Stühmer W, Wittka R, Wang X, Müller R, Ferrus A, Pongs O. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):8903-7.
Review An emerging pharmacology of peptide toxins targeted against potassium channels. [J Membr Biol. 1988]
Review An emerging pharmacology of peptide toxins targeted against potassium channels.
Moczydlowski E, Lucchesi K, Ravindran A. J Membr Biol. 1988 Oct; 105(2):95-111.
Review [Structural basis of the K+ channel inhibition by pore-blocking toxins, revealed by NMR]. [Tanpakushitsu Kakusan Koso. 2005]
Review [Structural basis of the K+ channel inhibition by pore-blocking toxins, revealed by NMR].
Takeuchi K, Shimada I. Tanpakushitsu Kakusan Koso. 2005 Aug; 50(10 Suppl):1297-302.

See reviews... See all...

Cited by 7 PubMed Central articles

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. [Toxicol Appl Pharmacol. 2011]
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.
Xia M, Shahane SA, Huang R, Titus SA, Shum E, Zhao Y, Southall N, Zheng W, Witt KL, Tice RR, et al. Toxicol Appl Pharmacol. 2011 May 1; 252(3):250-8. Epub 2011 Feb 26.
Histamine H(3) receptors mediate inhibition of noradrenaline release from intestinal sympathetic nerves. [Br J Pharmacol. 2000]
Histamine H(3) receptors mediate inhibition of noradrenaline release from intestinal sympathetic nerves.
Blandizzi C, Tognetti M, Colucci R, Del Tacca M. Br J Pharmacol. 2000 Apr; 129(7):1387-96.
Local movement in the S2 region of the voltage-gated potassium channel hKv2.1 studied using cysteine mutagenesis. [Biophys J. 2000]
Local movement in the S2 region of the voltage-gated potassium channel hKv2.1 studied using cysteine mutagenesis.
Milligan CJ, Wray D. Biophys J. 2000 Apr; 78(4):1852-61.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Structural basis of voltage-gated K+ channel pharmacology.
Structural basis of voltage-gated K+ channel pharmacology.
Trends Pharmacol Sci. 1992 Sep ;13(9):359-65.

PubMed
The influence of chlorpromazine on pathologic emotions and sexual unrest.
The influence of chlorpromazine on pathologic emotions and sexual unrest.
J Nerv Ment Dis. 1959 Aug ;129:171-6.

PubMed
Vive la différence!
Vive la différence!
Trends Neurosci. 1992 Sep ;15(9):331-2.

PubMed
Cystic fibrosis in the mouse by targeted insertional mutagenesis.
Cystic fibrosis in the mouse by targeted insertional mutagenesis.
Nature. 1992 Sep 17 ;359(6392):211-5.

PubMed
Psoriasis in association with sarcoidosis. Report of a case.
Psoriasis in association with sarcoidosis. Report of a case.
Arch Dermatol. 1960 Jun ;81:983-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Structural basis of voltage-gated K+ channel pharmacology.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 7 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information