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    Science. 1992 Jul 17;257(5068):401-3.

    Nitric oxide: a physiologic mediator of penile erection.

    Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH.

    Source

    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

    Abstract

    Nitric oxide (NO) is a cytotoxic agent of macrophages, a messenger molecule of neurons, and a vasodilator produced by endothelial cells. NO synthase, the synthetic enzyme for NO, was localized to rat penile neurons innervating the corpora cavernosa and to neuronal plexuses in the adventitial layer of penile arteries. Small doses of NO synthase inhibitors abolished electrophysiologically induced penile erections. These results establish NO as a physiologic mediator of erectile function.

    PMID:
    1378650
    [PubMed - indexed for MEDLINE]

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