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Immunol Today. 1992 Mar;13(3):93-100.

Endothelial cell interactions with granulocytes: tethering and signaling molecules.

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  • 1Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City 84112.


The adhesion of granulocytes to endothelial cells requires regulated expression of molecules on both the endothelial cell and the granulocyte. These pro-adhesive molecules have diverse structures and mechanisms of expression, and act either to tether the two cells together or as signals that induce activation-dependent adhesion events. Combinations of tethering and signaling molecules regulate endothelial-cell-granulocyte interactions at the endothelial surface.

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