Biochem J. 1992 Jun 15;284 ( Pt 3):749-54.

cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme.

McAllister G, Whiting P, Hammond EA, Knowles MR, Atack JR, Bailey FJ, Maigetter R, Ragan CI.

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Merck Sharp and Dohme Research Laboratories, Harlow, Essex, U.K.

Abstract

Inositol monophosphatase (EC 3.1.3.25) is a key enzyme in the phosphoinositide cell-signalling system. Its role is to provide inositol required for the resynthesis of phosphatidylinositol and polyphosphoinositides. It is the probable pharmacological target for lithium action in brain. Using probes derived from the bovine inositol monophosphatase cDNA we have isolated cDNA clones encoding the human and rat brain enzymes. The enzyme is highly conserved in all three species (79% identical). The coding region of the human cDNA was inserted into a bacterial expression vector. The expressed recombinant enzyme was purified and its biochemical properties examined. The human enzyme is very similar to the bovine enzyme.

PMID:: 1377913; [PubMed - indexed for MEDLINE]
PMCID:: PMC1132602

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Cited by 16 PubMed Central articles

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Structures reported by this article

Structural Studies Of Metal Binding By Inositol Monophosphatase: Evidence For Two-Metal Ion Catalysis

PDB: 1IMF

Source: Homo sapiens

Method: X-Ray Diffraction

Resolution: 2.5 Å

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cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme.

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