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Arch Pathol Lab Med. 1992 Mar;116(3):274-6.

Paneth cell-like metaplasia of the prostate gland.

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  • 1Department of Pathology, St Joseph's Medical Center, Yonkers, NY.

Abstract

We report two cases of Paneth cell-like metaplasia of the prostate gland, one in poorly differentiated carcinoma and the second in benign hyperplasia. By light microscopy, the Paneth-like cells were indistinguishable from Paneth cells found in the normal small intestine and ultrastructurally showed electron-dense granules typical of Paneth cells. Immunohistochemical stains were positive for prostate-specific antigen and prostatic acid phosphatase and negative for lysozyme and alpha 1-antitrypsin. The clinical significance of Paneth cell-like metaplasia is unknown and may represent an example of the multipotential metaplastic capability of actively dividing cells.

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PMID:
1371381
[PubMed - indexed for MEDLINE]
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