Science. 1961 Aug 4;134(3475):343.

Enzymatic formation of psychotomimetic metabolites from normally occurring compounds.

Abstract

An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine , mescaline, and dopamine.

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Further studies on the mode of action of psychotomimetic drugs: antagonism of the excitatory actions of 5-hydroxytryptamine by methylated derivatives of tryptamine. [Br J Pharmacol. 1974]
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Cited by 3 PubMed Central articles

Review When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor. [Sci Signal. 2009]
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Biochemistry of schizophrenia. [Postgrad Med J. 1963]
Biochemistry of schizophrenia.
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Enzymatic formation of psychotomimetic metabolites from normally occurring compounds.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

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Cited by 3 PubMed Central articles

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