Trends Biotechnol. 1992 Jul;10(7):247-56.

Bacillus subtilis and its relatives: molecular biological and industrial workhorses.

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Department of Microbiology, University of Newcastle upon Tyne, UK.

Abstract

The non-pathogenic bacterium Bacillus subtilis, since its first reported genetic transformation in 1959, has become a model system for the study of many aspects of the biochemistry, genetics and physiology of Gram-positive bacteria, and particularly of sporulation and associated metabolism. Extensive knowledge of the molecular biology of B. subtilis has led to the recent development of this bacterium as a host for the industrial production of heterologous proteins. Although difficulties have been encountered, these are being systematically addressed and overcome.

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