Curr Opin Biotechnol. 1992 Apr;3(2):110-4.

Mammalian cell culture processes.

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Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis 55455.

Abstract

Over the past year, mammalian cell culture research has been aimed at investigating the influence of culture conditions on viability, productivity and the consistency of post-translational modifications. Studies of the effect of medium conditions and the development of kinetic models are being made in relation to current efforts to develop fed-batch strategies that will optimize recombinant protein production processes. Recent advances have included novel biosensor and bioreactor developments. New technologies have also been applied to investigate high cell density bioreactor and culture conditions.

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Mammalian cell culture processes.

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