Curr Opin Biotechnol. 1991 Aug;2(4):539-43.

Chemical methods of protein synthesis and modification.

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SmithKline Beecham Pharmaceuticals, Medical Research Centre, Harlow, Essex, UK.

Abstract

Chemical and recombinant methods have continued to complement one another in the synthesis of protein analogues. Chemical methods remain particularly valuable when non-coded modifications are to be introduced, although it has been accepted since the commercialization of semisynthetic human insulin that they can also be used effectively for coded changes, in certain cases. The main objective of all such operations is not methodological, but is the production of molecules for practical use and further study. This goal has been reached frequently by chemical means during the past year.

PMID:: 1367673; [PubMed - indexed for MEDLINE]

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