Trends Biotechnol. 1991 Aug;9(8):279-84.

Strategies for improving plasmid stability in genetically modified bacteria in bioreactors.

Kumar PK, Maschke HE, Friehs K, Schügerl K.

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Institut für Technische Chemie, Universität Hannover, FRG.

Abstract

Exploitation of recombinant organisms for the large-scale, commercial production of foreign proteins is often hampered by the problem of plasmid instability. A wide range of strategies have been reported for improving the stability of recombinant organisms. A combination of manipulating both the genetic design of recombinants and the conditions of culturing the organisms may be used to achieve stable host-vector associations during culture of recombinant organisms in bioreactors.

PMID:: 1367568; [PubMed - indexed for MEDLINE]

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Strategies for improving plasmid stability in genetically modified bacteria in b...
Strategies for improving plasmid stability in genetically modified bacteria in bioreactors.
Trends Biotechnol. 1991 Aug ;9(8):279-84.

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Strategies for improving plasmid stability in genetically modified bacteria in bioreactors.

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Cited by 4 PubMed Central articles

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