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Pattern of adaptive control of levels of rat liver tryptophan transaminase.
The dual control by substrate and hormone of the level of a third adaptive enzyme in animals is described. Injections of hydrocortisone or the substrate tryptophan increased the level of the liver tryptophan-alpha-ketoglutarate transaminase of intact rats within 5 hours. In adrenalectomized rats this enzyme level was increased by hydrocortisone alone, but substrate induction could be demonstrated only if these animals were treated at the same time with hydrocortisone.
PMID: 13668514 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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The metabolism of L-tryptophan by isolated rat liver cells. Quantification of the relative importance of, and the effect of nutritional status on, the individual pathways of tryptophan metabolism.
Smith SA, Carr FP, Pogson CI.
Biochem J. 1980 Nov 15; 192(2):673-86.
[Biochem J. 1980]
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Tryptophan aminotransferase activity in rat liver.
Stanley JC, Nicholas AR, Dickson AJ, Thompson IM, Pogson CI.
Biochem J. 1984 May 15; 220(1):341-4.
[Biochem J. 1984]
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The 'permissive' effect of hydrocortisone on the induction of delta-aminolaevulate synthetase.
Marver HS, Collins A, Tschudy DP.
Biochem J. 1966 Jun; 99(3):31C-33C.
[Biochem J. 1966]
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Patient Drug Information
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Hydrocortisone Injection (A-hydroCort® , Hydrocortone® Acetate, Hydrocortone® Phosphate, ...)
Your doctor has ordered hydrocortisone, a corticosteroid, to relieve inflammation (swelling, heat, redness, and pain). The drug will be injected into a large muscle (such as your buttock or hip), into your vein, or added...