Bioessays. 1992 Dec;14(12):823-30.

DNA synthesis control in yeast: an evolutionarily conserved mechanism for regulating DNA synthesis genes?

Merrill GF, Morgan BA, Lowndes NF, Johnston LH.

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Department of Biochemistry and Biophysics, Oregon State University, Corvallis 97331.

Abstract

After yeast cells commit to the cell cycle in a process called START, genes required for DNA synthesis are expressed in late G1. Periodicity is mediated by a hexameric sequence, known as a MCB element, present in all DNA synthesis gene promoters. A complex that specifically binds MCBs has been identified. One polypeptide in the MCB complex is Swi6, a transcription factor that together with Swi4 also binds G1 cyclin promoters and participates in a positive feedback loop at START. The finding that Swi6 is directly involved in both START and DNA synthesis gene control suggest a model in which Swi6, activated through its participation in START, serves as the central transcription factor in coordinating late G1 gene expression. The mechanism may be conserved in all eukaryotic cells.

PMID:: 1365898; [PubMed - indexed for MEDLINE]

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A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast. [Nature. 1992]
A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast.
Dirick L, Moll T, Auer H, Nasmyth K. Nature. 1992 Jun 11; 357(6378):508-13.
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DNA synthesis control in yeast: an evolutionarily conserved mechanism for regulating DNA synthesis genes?

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