J Rheumatol. 1992 Nov;19(11):1672-7.

Sulfasalazine in early rheumatoid arthritis. The Australian Multicentre Clinical Trial Group.

[No authors listed]

Abstract

One hundred and five patients with a diagnosis of early nonerosive rheumatoid arthritis (RA) were randomized to receive enteric coated sulfasalazine as Salazopyrin En-tabs or placebo for 6 months. Sixty-five patients completed this 6 month treatment period. Patients taking sulfasalazine were significantly better than those taking placebo in terms of Ritchie articular index, number of swollen and tender joints and erythrocyte sedimentation rate. The sulfasalazine group also demonstrated a significant fall in serum hyaluronic acid, IgM rheumatoid factor and C-reactive protein concentration. Side effects leading to withdrawal from treatment occurred in 14 of the sulfasalazine group and 4 of the placebo group. The most common side effects of patients taking sulfasalazine were rashes, liver function test abnormalities and gastrointestinal upsets. Our study demonstrates the efficacy of sulfasalazine in early RA.

PMID:: 1362778; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

A controlled trial comparing sulfasalazine, gold sodium thiomalate, and placebo in rheumatoid arthritis. [Arthritis Rheum. 1988]
A controlled trial comparing sulfasalazine, gold sodium thiomalate, and placebo in rheumatoid arthritis.
Williams HJ, Ward JR, Dahl SL, Clegg DO, Willkens RF, Oglesby T, Weisman MH, Schlegel S, Michaels RM, Luggen ME. Arthritis Rheum. 1988 Jun; 31(6):702-13.
Validity of single variables and indices to measure disease activity in rheumatoid arthritis. [J Rheumatol. 1993]
Validity of single variables and indices to measure disease activity in rheumatoid arthritis.
van der Heijde DM, van 't Hof M, van Riel PL, van de Putte LB. J Rheumatol. 1993 Mar; 20(3):538-41.
Comparison between penicillamine and sulphasalazine in rheumatoid arthritis: Leeds-Birmingham trial. [Br Med J (Clin Res Ed). 1983]
Comparison between penicillamine and sulphasalazine in rheumatoid arthritis: Leeds-Birmingham trial.
Neumann VC, Grindulis KA, Hubball S, McConkey B, Wright V. Br Med J (Clin Res Ed). 1983 Oct 15; 287(6399):1099-102.
Review Sulfasalazine: a review of its use in the management of rheumatoid arthritis. [Drugs. 2005]
Review Sulfasalazine: a review of its use in the management of rheumatoid arthritis.
Plosker GL, Croom KF. Drugs. 2005; 65(13):1825-49.
Review Sulfasalazine for rheumatoid arthritis. [Cochrane Database Syst Rev. 2000]
Review Sulfasalazine for rheumatoid arthritis.
Suarez-Almazor ME, Belseck E, Shea B, Wells G, Tugwell P. Cochrane Database Syst Rev. 2000; (2):CD000958.

See reviews... See all...

Cited by 1 PubMed Central article

Rheumatoid arthritis. [Clin Evid (Online). 2007]
Rheumatoid arthritis.
Walker-Bone K, Farrow S. Clin Evid (Online). 2007 Aug 1; 2007. Epub 2007 Aug 1.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Sulfasalazine in early rheumatoid arthritis. The Australian Multicentre Clinical...
Sulfasalazine in early rheumatoid arthritis. The Australian Multicentre Clinical Trial Group.
J Rheumatol. 1992 Nov ;19(11):1672-7.

PubMed
Design of alkylating agents for selectivity of action.
Design of alkylating agents for selectivity of action.
Ann N Y Acad Sci. 1958 Apr 24 ;68(3):1238-45.

PubMed
Update on the search for DNA markers linked to manic-depressive illness in the O...
Update on the search for DNA markers linked to manic-depressive illness in the Old Order Amish.
J Psychiatr Res. 1992 Oct ;26(4):305-8.

PubMed
The use of plaster of paris to fill large defects in bone.
The use of plaster of paris to fill large defects in bone.
Am J Surg. 1959 Mar ;97(3):311-5.

PubMed
Electrolyte balance and enzyme synthesis pattern in rat salivary glands and panc...
Electrolyte balance and enzyme synthesis pattern in rat salivary glands and pancreas.
Am J Physiol. 1959 Feb ;196(2):365-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Sulfasalazine in early rheumatoid arthritis. The Australian Multicentre Clinical Trial Group.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information