J Psychiatr Res. 1992 Oct;26(4):305-8.

Update on the search for DNA markers linked to manic-depressive illness in the Old Order Amish.

Ginns EI, Egeland JA, Allen CR, Pauls DL, Falls K, Keith TP, Paul SM.

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Section on Molecular Neurogenetics, NIMH, Bethesda, MD 20892.

Abstract

In this report we describe our efforts to identify a gene involved in bipolar illness using a large, multigenerational Old Order Amish pedigree with many affected individuals. The original collection of cell lines from Amish pedigree 110 has been extended to include 169 individuals. We have used over 250 markers spaced at approximately 20 centiMorgans that detect restriction length fragment polymorphisms, but no LOD scores greater than 3 have been obtained from pairwise linkage analyses. We are expanding our collection of cell lines from both normal and affected family members and updating our diagnostic data as we continue our systematic screening of the genome for a gene involved in bipolar illness.

PMID:: 1362775; [PubMed - indexed for MEDLINE]

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A linkage study of distal chromosome 5q and bipolar disorder. [Biol Psychiatry. 1994]
A linkage study of distal chromosome 5q and bipolar disorder.
Mirow AL, Kristbjanarson H, Egeland JA, Shilling P, Helgason T, Gillin JC, Hirsch S, Kelsoe JR. Biol Psychiatry. 1994 Aug 15; 36(4):223-9.
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Cited by 1 PubMed Central article

Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish. [Am J Hum Genet. 1995]
Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish.
Pauls DL, Ott J, Paul SM, Allen CR, Fann CS, Carulli JP, Falls KM, Bouthillier CA, Gravius TC, Keith TP. Am J Hum Genet. 1995 Sep; 57(3):636-43.

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Update on the search for DNA markers linked to manic-depressive illness in the Old Order Amish.

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