Detection of a new polymorphism of the human proth...[Hum Genet. 1992]

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1: Hum Genet. 1992 Nov;90(3):325-6.Links

Detection of a new polymorphism of the human prothrombin (F2) gene by combination of PASA and mutated primer-mediated PCR-RFLP.

Iwahana H, Mizusawa N, Yoshimoto K, Itakura M.

Otsuka Department of Clinical and Molecular Nutrition, School of Medicine, University of Tokushima, Japan.

A new polymorphism of the human prothrombin (F2) gene was detected by a combination of polymerase chain reaction (PCR) amplification of specific alleles (PASA) and mutated primer-mediated PCR restriction fragment length polymorphism (PCR-RFLP). The method is simple and useful for detecting polymorphisms and mutations. The new polymorphism of C1 and C2 examined by this method is highly heterozygous and serves as a good human DNA marker.

PMID: 1362561 [PubMed - indexed for MEDLINE]

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Detection of a new polymorphism of the human prothrombin (F2) gene by combination of PASA and mutated primer-mediated PCR-RFLP.

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