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    J Med Genet. 1992 Dec;29(12):858-60.

    Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

    Crocq MA, Mant R, Asherson P, Williams J, Hode Y, Mayerova A, Collier D, Lannfelt L, Sokoloff P, Schwartz JC, et al.

    Centre Hospitalier, Rouffach, France.

    Comment in:

    Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

    PMID: 1362221 [PubMed - indexed for MEDLINE]

    PMCID: PMC1016201

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