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1: J Med Genet. 1992 Dec;29(12):858-60.Click here to read Click here to read Links
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J Med Genet. 1993 Aug;30(8):708.
J Med Genet. 1993 Aug;30(8):708-9.
J Med Genet. 1994 Mar;31(3):260.

Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

Crocq MA, Mant R, Asherson P, Williams J, Hode Y, Mayerova A, Collier D, Lannfelt L, Sokoloff P, Schwartz JC, et al.

Centre Hospitalier, Rouffach, France.

Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

PMID: 1362221 [PubMed - indexed for MEDLINE]

PMCID: PMC1016201