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Hautarzt. 1992 Dec;43(12):772-4.

[Ammonium bituminosulfonate (Ichthyol). Anti-inflammatory effect and inhibition of the 5-lipoxygenase enzyme].

[Article in German]

Author information

  • 1Dermatologische Klinik und Poliklinik Universität Rostock.

Abstract

Ammonium bituminosulphonate (Ichthyol) inhibits 5-lipoxygenase activity in human polymorphonuclear neutrophils. The inhibition is dose-dependent and occurs at non-cytotoxic concentrations of the drug. This results in a decreased release of Leukotriene B4 from polymorphonuclear neutrophils. Furthermore, when applied to the ear skin of AB/Bln mice pretreated with croton oil, Ichthyol reduces the inflammatory reaction.

PMID:
1361926
[PubMed - indexed for MEDLINE]
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