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Lancet. 1993 Feb 27;341(8844):570-1.
Insemination of HIV-negative women with processed semen of HIV-positive partners.
Department of Obstetrics and Gynecology, San Paolo Biomedical Institute, University of Milan Medical School, Italy.
Many HIV-discordant couples want to have children so much that they are willing to abandon condom-protected sexual intercourse irrespective of the risks. Previous testing in our laboratory showed that gradient centrifugation followed by a swim-up procedure effectively removed HIV-1-infected cells from the semen of HIV-seropositive men. 85 HIV-discordant couples were screened for fertility; 29 women were found suitable for a timed insemination course with the processed semen of their HIV-seropositive partner. None of the inseminated women seroconverted, and 17 pregnancies were achieved in 15 women. All 10 babies born to these mothers remain HIV seronegative. The findings may help in the counselling of such couples and also give them hope of having healthy babies.
PMID: 1360037 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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ReviewShould HIV discordant couples have access to assisted reproductive technologies?
Spriggs M, Charles T.
J Med Ethics. 2003 Dec; 29(6):325-9.
[J Med Ethics. 2003]
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ReviewUse of assisted reproductive technology to reduce the risk of transmission of HIV in discordant couples wishing to have their own children where the male partner is seropositive with an undetectable viral load.
Baker HW, Mijch A, Garland S, Crowe S, Dunne M, Edgar D, Clarke G, Foster P, Blood J.
J Med Ethics. 2003 Dec; 29(6):315-20.
[J Med Ethics. 2003]
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ReviewViruses in the mammalian male genital tract and their effects on the reproductive system.
Dejucq N, Jégou B.
Microbiol Mol Biol Rev. 2001 Jun; 65(2):208-31 ; first and second pages, table of contents.
[Microbiol Mol Biol Rev. 2001]
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