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    Science. 1992 Nov 6;258(5084):985-7.

    Reductase activity encoded by the HM1 disease resistance gene in maize.

    Johal GS, Briggs SP.

    Department of Biotechnology Research, Pioneer Hi-Bred International, Inc., Johnston, IA 50131.

    The HM1 gene in maize controls both race-specific resistance to the fungus Cochliobolus carbonum race 1 and expression of the NADPH (reduced form of nicotinamide adenine dinucleotide phosphate)-dependent HC toxin reductase (HCTR), which inactivates HC toxin, a cyclic tetrapeptide produced by the fungus to permit infection. Several HM1 alleles were generated and cloned by transposon-induced mutagenesis. The sequence of wild-type HM1 shares homology with dihydroflavonol-4-reductase genes from maize, petunia, and snap-dragon. Sequence homology is greatest in the beta alpha beta-dinucleotide binding fold that is conserved among NADPH- and NADH (reduced form of nicotinamide adenine dinucleotide)-dependent reductases and dehydrogenases. This indicates that HM1 encodes HCTR.

    PMID: 1359642 [PubMed - indexed for MEDLINE]

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