J Pharm Pharmacol. 1992 Aug;44(8):663-6.

Effects of isosorbide-5-mononitrate and isosorbide-2-mononitrate on the contractile and electrical activity and on the content of cyclic nucleotides in isolated heart muscles of the guinea-pig and dog.

Atanassova R, Spassov G, Balansky R, Boev K.

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Chemical Pharmaceutical Research Institute, Sofia, Bulgaria.

Abstract

Isosorbide-5-mononitrate and isosorbide-2-mononitrate, the metabolites of isosorbide dinitrate, were studied for their effects on the contractile and electrical activity and on the content of cyclic nucleotides in isolated heart muscles of guinea-pig and dog. Isosorbide-5-mononitrate at all concentrations tested and isosorbide-2-mononitrate at low concentrations did not produce significant changes in the mechanical activity of guinea-pig heart preparations. Isosorbide-2-mononitrate in concentrations above 10(-4) M inhibited the contractility and shortened the action potential of guinea-pig and dog heart muscle. Neither mononitrate had an effect on cAMP concentration but both induced a significant elevation of cGMP content in guinea-pig heart tissue, the effect of isosorbide-2-mononitrate being greater.

PMID:: 1359091; [PubMed - indexed for MEDLINE]

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Effects of isosorbide-5-mononitrate and isosorbide-2-mononitrate on the contract...
Effects of isosorbide-5-mononitrate and isosorbide-2-mononitrate on the contractile and electrical activity and on the content of cyclic nucleotides in isolated heart muscles of the guinea-pig and dog.
J Pharm Pharmacol. 1992 Aug ;44(8):663-6.

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