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    Biochim Biophys Acta. 1992 Oct 20;1132(3):329-31.

    Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase.

    Russ AP, Ruzicka V, Maerz W, Appelhans H, Gross W.

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    Gustav Embden-Zentrum der biologischen Chemie, J.W. Goethe-Universität, Frankfurt, Germany.

    Abstract

    Cytosolic 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase (E.C. 4.1.3.5) is a highly regulated enzyme involved in isoprenoid biosynthesis and therefore a potential target for cholesterol-lowering drugs. Up to now, primary structure data have only been available for chicken, rat and hamster HMG-CoA synthase. Using in vitro amplification and direct sequencing, we have determined the nucleotide sequence of the coding region of the human cytosolic 3-hydroxy-3-methylglutaryl CoA synthase cDNA.

    PMID:
    1358203
    [PubMed - indexed for MEDLINE]

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