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Lancet. 1992 Oct 31;340(8827):1067-8.

Fatal myocardial infarction and use of psychotropic drugs in young women.

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  • 1Department of Public Health and Primary Care, University of Oxford, UK.

Erratum in

  • Lancet 1992 Nov 28;340(8831):1362.


We have observed an unexpected 17-fold increase in risk of fatal [corrected] myocardial infarction (relative risk 16.9, 95% confidence interval 3.9-72.8) associated with current use of psychotropic drugs. This incidental finding, in a case-control study of cardiovascular mortality in women aged 16-39 not designed to test any hypothesis about psychotropic drugs, should be treated cautiously. There is, however, evidence of a relation between psychiatric morbidity and cardiovascular disease and the association recorded here requires further investigation.

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