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Brain Res. 1992 Jun 12;582(2):349-52.

The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats.

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  • 1Department of Pharmacology, College of Medicine, University of California, Irvine 92717.

Erratum in

  • Brain Res 1992 Sep 25;591(2):359.


The reported failure of the prototypical (but partial) D1 agonist SKF 38393 to support self-administration behavior contradicts hypotheses of D1-mediated reinforcement. Here we demonstrate that rats will readily self-administer two SKF 38393 analogs, the partial D1 agonist SKF 77434 and the full D1 agonist SKF 82958; both compounds produce inverted U-shaped dose-response curves. When compared to the parent compound, both analogs display enhanced lipophilicity and somewhat decreased D1/D2 selectivity. It is suggested that these properties, rather than partial D1 agonist efficacy, explain the failure of SKF 38393 to act as a reinforcer.

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