Neurol Res. 1992;14(2 Suppl):128-31.

Age-related decline of cerebral oxygen metabolism in normal population detected with positron emission tomography.

Takada H, Nagata K, Hirata Y, Satoh Y, Watahiki Y, Sugawara J, Yokoyama E, Kondoh Y, Shishido F, Inugami A, et al.

Source

Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan.

Abstract

Using positron emission tomography (PET), cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) were measured in 32 healthy volunteers aged from 27 to 67 years. In bilateral putamen, left supratemporal, left infrafrontal and left parietal cortices, CMRO2 showed a significant decline during aging. The age-related decline of CBF was seen only at the left superior temporal cortex. The mean CMRO2 was significantly lower in the elder group (over 51 years old) than in the younger group (under 50 years old), whereas no significant difference in mean CBF between the two groups. The poor correlation of CBF to the age could be explained partly by the fact that CBF is easily influenced by the physiological, psychological and/or environmental factors. The age-related changes of CMRO2 were more marked in the association cortices of the left hemisphere than in that of the right hemisphere.

PMID:: 1355868; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Comparative Study

MeSH Terms

LinkOut - more resources

Medical

Seniors' Health - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

[Studies of cerebral blood flow and metabolism in patients with senile dementia of the Alzheimer's type and diagnostic evaluation of the dementing illnesses by positron emission tomography]. [Nihon Ika Daigaku Zasshi. 1990]
[Studies of cerebral blood flow and metabolism in patients with senile dementia of the Alzheimer's type and diagnostic evaluation of the dementing illnesses by positron emission tomography].
Sakamoto S. Nihon Ika Daigaku Zasshi. 1990 Jun; 57(3):222-34.
Reduction in regional cerebral metabolic rate of oxygen during human aging. [Stroke. 1986]
Reduction in regional cerebral metabolic rate of oxygen during human aging.
Yamaguchi T, Kanno I, Uemura K, Shishido F, Inugami A, Ogawa T, Murakami M, Suzuki K. Stroke. 1986 Nov-Dec; 17(6):1220-8.
[Measurements of cerebral blood flow and metabolism in patients with Alzheimer's disease]. [Rinsho Byori. 1990]
[Measurements of cerebral blood flow and metabolism in patients with Alzheimer's disease].
Kitamura S, Terashi A. Rinsho Byori. 1990 May; 38(5):494-8.
Review [The use of radionuclides, specifically positron-emission tomography, in the determination of the blood circulation and metabolism of the brain. Application in experimental cerebral embolism]. [Verh K Acad Geneeskd Belg. 1989]
Review [The use of radionuclides, specifically positron-emission tomography, in the determination of the blood circulation and metabolism of the brain. Application in experimental cerebral embolism].
Weyne J, de Ley G. Verh K Acad Geneeskd Belg. 1989; 51(4):315-76.
Review Human cerebral circulation: positron emission tomography studies. [Ann Nucl Med. 2005]
Review Human cerebral circulation: positron emission tomography studies.
Ito H, Kanno I, Fukuda H. Ann Nucl Med. 2005 Apr; 19(2):65-74.

See reviews... See all...

Cited by 5 PubMed Central articles

Brain aging research at the close of the 20th century: from bench to bedside. [Dialogues Clin Neurosci. 2001]
Brain aging research at the close of the 20th century: from bench to bedside.
Cidis Meltzer C, Francis PT. Dialogues Clin Neurosci. 2001 Sep; 3(3):167-80.
Review The postictal state: effects of age and underlying brain dysfunction. [Epilepsy Behav. 2010]
Review The postictal state: effects of age and underlying brain dysfunction.
Theodore WH. Epilepsy Behav. 2010 Oct; 19(2):118-20. Epub 2010 Aug 17.
Neurometabolic coupling in the lateral geniculate nucleus changes with extended age. [J Neurophysiol. 2010]
Neurometabolic coupling in the lateral geniculate nucleus changes with extended age.
Li B, Freeman RD. J Neurophysiol. 2010 Jul; 104(1):414-25. Epub 2010 May 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Age-related decline of cerebral oxygen metabolism in normal population detected ...
Age-related decline of cerebral oxygen metabolism in normal population detected with positron emission tomography.
Neurol Res. 1992 ;14(2 Suppl):128-31.

PubMed
The mode of action of prostigmin in heartburn of pregnancy.
The mode of action of prostigmin in heartburn of pregnancy.
West J Surg Obstet Gynecol. 1958 May-Jun ;66(3):161-2.

PubMed
Smoking as "independent" risk factor for suicide: illustration of an artifact fr...
Smoking as "independent" risk factor for suicide: illustration of an artifact from observational epidemiology?
Lancet. 1992 Sep 19 ;340(8821):709-12.

PubMed
Auscultation as an important aid to the diagnosis of fractures.
Auscultation as an important aid to the diagnosis of fractures.
Surg Gynecol Obstet. 1958 Jun ;106(6):713-4.

PubMed
Parental origin of the X chromosomes in Rett syndrome.
Parental origin of the X chromosomes in Rett syndrome.
Am J Med Genet. 1992 Sep 1 ;44(1):121-3.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: