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1: Br J Clin Pharmacol. 1992 Jul;34(1):85-7.Click here to read Links

Impairment of carbamazepine-10, 11-epoxide elimination by valnoctamide, a valpromide isomer, in healthy subjects.

Pisani F, Fazio A, Artesi C, Oteri G, Spina E, Tomson T, Perucca E.

Institute of Neurological and Neurosurgical Sciences, University of Messina, Italy.

The effect of the valpromide isomer valnoctamide (VCD, 200 mg three times daily for 8 days), an over-the-counter tranquillizer, on the elimination kinetics of a single oral dose of carbamazepine-10, 11-epoxide (CBZ-E, 100 mg) was investigated in healthy subjects. During VCD treatment, the half-life of CBZ-E was prolonged significantly compared with control (19.7 +/- 6.7 h vs 6.9 +/- 2.0 h, means +/- s.d., P less than 0.01), and its oral clearance decreased four-fold (from 109.6 +/- 30.7 to 28.8 +/- 11.1 ml h-1 kg-1, P less than 0.01). These findings indicate that VCM, like valpromide, strongly inhibits epoxide hydrolase in vivo.

PMID: 1352988 [PubMed - indexed for MEDLINE]

PMCID: PMC1381382

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