Abstract
The cDNA coding for the human dipeptidyl peptidase IV (DPPIV) has been isolated and sequenced. The nucleotide sequence (3465 bp) of the cDNA contains an open reading frame encoding a polypeptide comprising 766 amino acids, one residue less than those of rat DPPIV. The predicted amino acid sequence exhibits 84.9% identity to that of the rat enzyme, and contains nine potential N-linked glycosylation sites, one site more than those in the rat enzyme. A putative catalytic triad for serine proteinases, serine, aspartic acid and histidine, are found in a completely conserved COOH-terminal region (positions 625-752).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Cloning, Molecular
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Dipeptidyl Peptidase 4
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / chemistry
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / genetics*
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Humans
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / genetics*
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Molecular Sequence Data
Substances
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Membrane Glycoproteins
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
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Dipeptidyl Peptidase 4
Associated data
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GENBANK/M80530
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GENBANK/M80531
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GENBANK/M80532
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GENBANK/M80533
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GENBANK/M91429
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GENBANK/M91430
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GENBANK/X60708
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GENBANK/X64342
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GENBANK/X64343
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GENBANK/X64766