Biochem Biophys Res Commun. 1992 Jun 30;185(3):826-32.

Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.

Sugihara H, Moriyoshi K, Ishii T, Masu M, Nakanishi S.

Source

Institute for Immunology, Kyoto University Faculty of Medicine, Japan.

Abstract

We here report the existence of 6 additional isoforms of the NMDA receptor generated via alternative splicing by molecular analysis of cDNA clones isolated from a rat forebrain cDNA library. These isoforms possess the structures with an insertion at the extracellular amino-terminal region or deletions at two different extracellular carboxyl-terminal regions, or those formed by combinations of the above insertion and deletions. One of the deletions results in the generation of a new carboxyl-terminal sequence. All these isoforms possess the ability to induce electrophysiological responses to NMDA and respond to various antagonists selective to the NMDA receptor in the Xenopus oocyte expression system. In addition, a truncated form of the NMDA receptor also exists that contains only the extreme amino-terminal sequence of this protein molecule. These data indicate that the NMDA receptor consists of heterogeneous molecules that differ in the extracellular sequence of the amino- and carboxyl-terminal regions.

PMID:: 1352681; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

MeSH Terms

Substances

Secondary Source ID

LinkOut - more resources

Full Text Sources

Elsevier Science

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor. [J Biol Chem. 1993]
Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.
Karp SJ, Masu M, Eki T, Ozawa K, Nakanishi S. J Biol Chem. 1993 Feb 15; 268(5):3728-33.
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain. [Proc Natl Acad Sci U S A. 1993]
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.
Planells-Cases R, Sun W, Ferrer-Montiel AV, Montal M. Proc Natl Acad Sci U S A. 1993 Jun 1; 90(11):5057-61.
Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C. [Proc Natl Acad Sci U S A. 1992]
Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.
Durand GM, Gregor P, Zheng X, Bennett MV, Uhl GR, Zukin RS. Proc Natl Acad Sci U S A. 1992 Oct 1; 89(19):9359-63.
Alteration of Ca2+ permeability and sensitivity to Mg2+ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor. [J Biol Chem. 1993]
Alteration of Ca2+ permeability and sensitivity to Mg2+ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor.
Sakurada K, Masu M, Nakanishi S. J Biol Chem. 1993 Jan 5; 268(1):410-5.
Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. [J Biol Chem. 1993]
Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.
Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa C, Shigemoto R, Mizuno N, Masu M. J Biol Chem. 1993 Feb 5; 268(4):2836-43.

See reviews... See all...

Cited by 33 PubMed Central articles

NMDA receptor subunit expression in the supraoptic nucleus of adult rats: dominance of NR2B and NR2D. [Brain Res. 2011]
NMDA receptor subunit expression in the supraoptic nucleus of adult rats: dominance of NR2B and NR2D.
Doherty FC, Sladek CD. Brain Res. 2011 May 4; 1388:89-99. Epub 2011 Mar 31.
Separation of domain contacts is required for heterotetrameric assembly of functional NMDA receptors. [J Neurosci. 2011]
Separation of domain contacts is required for heterotetrameric assembly of functional NMDA receptors.
Farina AN, Blain KY, Maruo T, Kwiatkowski W, Choe S, Nakagawa T. J Neurosci. 2011 Mar 9; 31(10):3565-79.
NMDA Receptors and Colitis: Basic Science and Clinical Implications. [Rev Analg. 2008]
NMDA Receptors and Colitis: Basic Science and Clinical Implications.
Zhou Q, Nicholas Verne G. Rev Analg. 2008 Nov 1; 10(1):33-43.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Structures and properties of seven isoforms of the NMDA receptor generated by al...
Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.
Biochem Biophys Res Commun. 1992 Jun 30 ;185(3):826-32.

PubMed
[Dependence of the nitrous oxide anesthesia threshold on excitement states & met...
[Dependence of the nitrous oxide anesthesia threshold on excitement states & metabolism].
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1957 ;231(2):141-8.

PubMed
Positron emission tomographic analysis of central D1 and D2 dopamine receptor oc...
Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects.
Arch Gen Psychiatry. 1992 Jul ;49(7):538-44.

PubMed
Henry Whitehead and cholera in Broad Street.
Henry Whitehead and cholera in Broad Street.
Med Hist. 1958 Apr ;2(2):92-108.

PubMed
Management of a major box jellyfish (Chironex fleckeri) sting. Lessons from the ...
Management of a major box jellyfish (Chironex fleckeri) sting. Lessons from the first minutes and hours.
Med J Aust. 1992 May 4 ;156(9):655-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: