Hum Genet. 1992 Jun;89(4):381-3.

Genetic heterogeneity of early-onset familial breast cancer.

Sobol H, Mazoyer S, Narod SA, Smith SA, Black DM, Kerbrat P, Jamot B, Solomon E, Ponder BA, Guerin D.

Source

Oncology-Genetics Unit, Centre Léon Bérard, Lyon, France.

Abstract

A gene for early-onset familial breast cancer has recently been mapped to the chromosome 17q12-23 region. In order to confirm the gene location, we have tested an extensive early-onset breast cancer family with 4 markers in this chromosome region. Linkage was negative with all 4 markers. This study suggests that there is genetic heterogeneity among early-onset breast cancer families.

PMID:: 1352270; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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Genetic Markers

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Medical

Breast Cancer - MedlinePlus Health Information

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Related citations in PubMed

Closing in on a breast cancer gene on chromosome 17q. [Am J Hum Genet. 1992]
Closing in on a breast cancer gene on chromosome 17q.
Hall JM, Friedman L, Guenther C, Lee MK, Weber JL, Black DM, King MC. Am J Hum Genet. 1992 Jun; 50(6):1235-42.
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Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.
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Linkage to markers for the chromosome region 17q12-q21 in 13 Dutch breast cancer kindreds.
Devilee P, Cornelis RS, Bootsma A, Bardoel A, van Vliet M, van Leeuwen I, Cleton FJ, de Klein A, Lindhout D, Vasen HF. Am J Hum Genet. 1993 Apr; 52(4):730-5.
Review Familial risk and genetic susceptibility for breast cancer. [Cancer Causes Control. 1994]
Review Familial risk and genetic susceptibility for breast cancer.
Eby N, Chang-Claude J, Bishop DT. Cancer Causes Control. 1994 Sep; 5(5):458-70.
Review The search for the familial breast/ovarian cancer gene. [Trends Genet. 1993]
Review The search for the familial breast/ovarian cancer gene.
Black DM, Solomon E. Trends Genet. 1993 Jan; 9(1):22-6.

See reviews... See all...

Cited by 3 PubMed Central articles

Linkage analysis in German breast cancer families with early onset of the disease, using highly polymorphic markers from the chromosome 17q11-q24 region. [Am J Hum Genet. 1993]
Linkage analysis in German breast cancer families with early onset of the disease, using highly polymorphic markers from the chromosome 17q11-q24 region.
Zimmermann W, Bender E, Rohde K, Reis A, Wiseman R, Futreal A, Krause H, Prokoph H, Werner S, Scherneck S. Am J Hum Genet. 1993 Apr; 52(4):789-91.
Linkage analysis of 19 French breast cancer families, with five chromosome 17q markers. [Am J Hum Genet. 1993]
Linkage analysis of 19 French breast cancer families, with five chromosome 17q markers.
Mazoyer S, Lalle P, Narod SA, Bignon YJ, Courjal F, Jamot B, Dutrillaux B, Stoppa-Lyonnett D, Sobol H. Am J Hum Genet. 1993 Apr; 52(4):754-60.
An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium. [Am J Hum Genet. 1995]
An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.
Narod SA, Ford D, Devilee P, Barkardottir RB, Lynch HT, Smith SA, Ponder BA, Weber BL, Garber JE, Birch JM. Am J Hum Genet. 1995 Jan; 56(1):254-64.

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