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J Immunol. 1992 Jun 1;148(11):3618-23.

Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.

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  • 1Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304.


The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence (Moore, K. W., et al. 1990. Science 248:1230; 250:494) revealed the presence of five exons that span approximately 5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1.

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