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    J Immunol. 1992 Jun 1;148(11):3618-23.

    Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.

    Source

    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304.

    Abstract

    The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence (Moore, K. W., et al. 1990. Science 248:1230; 250:494) revealed the presence of five exons that span approximately 5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1.

    PMID:
    1350294
    [PubMed - indexed for MEDLINE]

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