Hum Genet. 1992 Apr;89(1):33-6.

Anonymous markers located on chromosome 6 in the HLA-A class I region: allelic distribution in genetic haemochromatosis.

Boretto J, Jouanolle AM, Yaouanq J, el Kahloun A, Mauvieux V, Blayau M, Perichon M, Le Treut A, Clayton J, Borot N, et al.

Source

Centre d'Immunologie INSERM-CNRS, Marseille, France.

Abstract

Two yeast artificial chromosomes of the HLA class I region were subcloned. Four of the subclones studied displayed restriction polymorphisms that corresponded to six bi-allelic series. Allelic distribution of the anonymous markers was then studied by comparing a control population with a group of patients with familial haemochromatosis. Only one marker presents an unequivocal association with the haemochromatosis gene and is 100 kb centromeric to HLA-A. This association however is not as strong as with HLA-A3. The results suggest two possible locations for the haemochromatosis gene: less than 100 kb centromeric to the HLA-A locus, or on the telomeric side.

PMID:: 1349563; [PubMed - indexed for MEDLINE]

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Anonymous marker loci within 400 kb of HLA-A generate haplotypes in linkage disequilibrium with the hemochromatosis gene (HFE) [Am J Hum Genet. 1994]
Anonymous marker loci within 400 kb of HLA-A generate haplotypes in linkage disequilibrium with the hemochromatosis gene (HFE)
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Cited by 3 PubMed Central articles

Allelic association under map error and recombinational heterogeneity: a tale of two sites. [Proc Natl Acad Sci U S A. 1998]
Allelic association under map error and recombinational heterogeneity: a tale of two sites.
Lonjou C, Collins A, Ajioka RS, Jorde LB, Kushner JP, Morton NE. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11366-70.
Anonymous marker loci within 400 kb of HLA-A generate haplotypes in linkage disequilibrium with the hemochromatosis gene (HFE) [Am J Hum Genet. 1994]
Anonymous marker loci within 400 kb of HLA-A generate haplotypes in linkage disequilibrium with the hemochromatosis gene (HFE)
Yaouanq J, Perichon M, Chorney M, Pontarotti P, Le Treut A, el Kahloun A, Mauvieux V, Blayau M, Jouanolle AM, Chauvel B. Am J Hum Genet. 1994 Feb; 54(2):252-63.
Allelic associations and homozygosity at loci from HLA-B to D6S299 in genetic haemochromatosis. [J Med Genet. 1995]
Allelic associations and homozygosity at loci from HLA-B to D6S299 in genetic haemochromatosis.
Raha-Chowdhury R, Bowen DJ, Burnett AK, Worwood M. J Med Genet. 1995 Jun; 32(6):446-52.

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