-
The role of cell division in the induction of clonal anergy.
Dept of Microbiology, University of Minnesota Medical School, Minneapolis 55455.
The interaction of antigen with lymphocyte antigen receptors can result in either clonal expansion or unresponsiveness (anergy). In 1970, Bretscher and Cohn proposed a two-signal model of lymphocyte activation to explain this paradox: antigen receptor occupancy alone could induce unresponsiveness whereas antigen receptor occupancy plus a costimulatory signal could induce immunity. Here, Marc Jenkins reviews in vitro and in vivo manifestations of clonal anergy and evaluates the ability of the two-signal model to explain these phenomena.
PMID: 1349483 [PubMed - indexed for MEDLINE]
-
Cited by 21 PubMed Central articles
-
ReviewLupus nephritis: the central role of nucleosomes revealed.
Mortensen ES, Fenton KA, Rekvig OP.
Am J Pathol. 2008 Feb; 172(2):275-83. Epub 2008 Jan 10.
[Am J Pathol. 2008]
-
CD40-deficient dendritic cells producing interleukin-10, but not interleukin-12, induce T-cell hyporesponsiveness in vitro and prevent acute allograft rejection.
Gao JX, Madrenas J, Zeng W, Cameron MJ, Zhang Z, Wang JJ, Zhong R, Grant D.
Immunology. 1999 Oct; 98(2):159-70.
[Immunology. 1999]
-
Induction of abortive and productive proliferation in resting human T lymphocytes via CD3 and CD28.
Müller Y, Wolf H, Wierenga E, Jung G.
Immunology. 1999 Jun; 97(2):280-6.
[Immunology. 1999]
- » See all...