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Science. 1992 Mar 20;255(5051):1573-6.

Transcription factor loading on the MMTV promoter: a bimodal mechanism for promoter activation.

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  • 1Hormone Action and Oncogenesis Section, Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892.

Erratum in

  • Science 1992 Apr 10;256(5054):161.


The mouse mammary tumor virus (MMTV) promoter attains a phased array of six nucleosomes when introduced into rodent cells. This architecture excludes nuclear factor 1/CCAAT transcription factor (NF1/CTF) from the promoter before glucocorticoid treatment and hormone-dependent access of nucleolytic agents to promoter DNA. In contrast, when the promoter was transiently introduced into cells, NF1/CTF was bound constitutively and nucleolytic attack was hormone-independent. Thus, induction at this promoter was a bimodal process involving receptor-dependent remodeling of chromatin that allows NF1/CTF loading and direct receptor-mediated recruitment of additional transcription factors.

[PubMed - indexed for MEDLINE]
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