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Nature. 1992 Jan 2;355(6355):50-5.

Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents.

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  • 1Department of Pharmacology, University of California, San Francisco 94143-0450.


Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.

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