Int J Neurosci. 1992 Jul-Aug;65(1-4):83-90.

Melatonin and petit-mal epilepsy: an hypothesis.

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Democrition University of Thrace, Department of Medical Physics, Greece.

Abstract

Intraventricular administration of the opioid peptide leucine-enkephalin has been reported to induce petit-mal-like seizures in rats. These seizures have been found to be an age-dependent phenomenon. In rats, the full manifestation of these seizures develops after 4 weeks of age during which time ethosuximide was effective in aborting these seizures, while phenytoin and phenobarbital were ineffective. The period associated with the development of enkephalin-induced seizures in rats coincides with an important milestone in pineal chronobiology. In rats, melatonin plasma levels peak at 3 weeks of age, a period which also corresponds with the emergence of melatonin circadian rhythms. It is proposed that melatonin mediates the anticonvulsant action of drugs effective for petit-mal (absence) epilepsy and that the pineal gland is implicated in the pathogenesis of this form of childhood epilepsy.

PMID:: 1341694; [PubMed - indexed for MEDLINE]

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Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin. [Science. 1980]
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Melatonin and petit-mal epilepsy: an hypothesis.

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