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1: Genomics. 1992 Feb;12(2):412-6.Click here to read Links

Human choline acetyltransferase (CHAT): partial gene sequence and potential control regions.

Toussaint JL, Geoffroy V, Schmitt M, Werner A, Garnier JM, Simoni P, Kempf J.

Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.

Choline acetyltransferase (CHAT) (EC 2.3.1.6) is the biosynthetic enzyme for the neurotransmitter acetylcholine in the central and peripheral nervous systems. In this study, a human CHAT genomic clone has been isolated and partially sequenced at its 5' end. This fragment contains the first four exons with an ACG initiator codon and potential control regions including TATA, CAAT, GC boxes, and several transcription control sequences. A comparison of the primary structure of CHAT among pig, rat, mouse, and Drosophila is presented.

PMID: 1339386 [PubMed - indexed for MEDLINE]